Crossing time zones is torturous enough without the prospect of being battered by Robert Huth or Ryan Shawcross the following weekend. You are sat waiting for your case to come round on the tediously slow carousel, wondering if it is actually possible to sleep for six weeks - we've all been there.

Jet lag is a surreal feeling and it justifies a lot of napping, which is great - usually.

Premier League footballers aren't likely sitting in squashed seats on their long haul flights eating plastic food, but long-distance travelling will take it's toll on anyone - and the international break is certainly taking a toll on Premier League football clubs.

Manchester City are the hardest hit by the schedule. Sergio Aguero, Nicolas Otamendi and Pablo Zabaleta were all in action for Argentina, while the Premier League's most under-valued player, Fernandinho, played for Brazil in South America too. Long journeys might take their toll on the side and could force Pep Guardiola to rotate his team. Claudio Bravo was also in action in South America, but the Chilean is unlikely to be rested.

Pushing Pep Guardiola close for the jet lag frustration of the week award is Jurgen Klopp. His two Brazilian magicians, Philippe Coutinho and Roberto Firmino, featured in South America. Firmino was an unused sub in their game with Venezuela on Tuesday and you would expect he will be nearly at 100% this weekend. Coutinho played almost every minute of the two games, however, and could struggle for the weekend.

Manchester United and Chelsea will both have question marks surrounding the freshness of players too. Antonio Valencia, Marcos Rojo and Willian were all in action on Tuesday and could be short of training time ahead of their weekend fixtures.

Across the rest of the league, no team is suffering from more than one recognised first team player having to travel across multiple time zones. Body clock adjustments aren't exactly as severe when you've been playing in Eastern Europe, that would be a pretty weak excuse for underperforming.

However, one club could be hurt badly. Arsenal face the regular dilemma around Alexis Sanchez, who featured twice for Chile. His performances after international breaks have been inconsistent throughout his time in the Premier League.

Elsewhere, Leicester's unheralded hero of last hero, Shinji Okazaki, will likely still be recovering and West Brom's Salomon Rondon could be suffering a little. Abel Hernandez may need a rest for Hull's game against Bournemouth on Saturday, too.

Heung-Min Son's excellent form for Spurs continued, although Mauricio Pochettino might be tempted to give him a few days off ahead of a trip to Leverkusen next week. It really would be so very Spursy if Son, who has finally looked the part for Pochettino's side, played and picked up an injury.

Stoke and Watford could leave out Geoff Cameron and Juan Carlos Paredes respectively as well, with both players having to adapt back to British time once again. Cameron enjoyed a successful break, however, and has been a key player in balancing the Stoke side.

Many of these players will be absolutely fine, of course, but some will return fatigued and it could leave managers uncertain about their selection. Changing time zones isn't exactly the greatest challenge these elite athletes will face, but resting a player for one game this weekend defintely beats losing him for next three.