It is a year to the day since Bayern won 3-1 at the Emirates at the same stage of the competition, on route to winning the tournament.
And now Guardiola is set to see his side return to the Emirates as they bid to become the first side to successfully retain the Champions League trophy.
The former Barcelona manager said: “It’s my third time as a trainer here to play against Arsenal. I’ve never won here.
“I learnt that you can’t dominate 90 minutes against Arsenal. It’s impossible.
“You can play good, you can dominate during half-time, 30 minutes, 75 minutes, but complete 90 minutes it’s impossible. Always you have a problem.
“We’ll try to make a good game, as best as possible; don’t think too much about the second game, concentrate on what we have to do tomorrow. And I hope it goes well.
“It’s a good test tomorrow to know what is our level in Europe this year.”
After last season’s treble winning campaign, expectations surrounding Bayern are higher than ever.
But Guardiola insists he is not yet thinking about becoming the first team since the great AC Milan side of 1990 to retain the trophy.
He added: “My target is play every week better than the week before.
“I know when we don’t win everything it will be a little bit disappointing, but I know how difficult it is to win.
“The title is so difficult. It’s not happened since the 90s. I’m not worried about that. I’m not concerned about that.
“We’re going to look forward to always getting better.”