Paul Lambert has taken the bold decision to drop star striker Christian Benteke for the trip to Southampton.
The Belgian striker has been out of form in recent games is replaced by Czech striker Libor Kozak, while Andreas Wiemann misses out to Nathan Baker.
For Southampton, Paolo Gazzinga replaces Artur Boruc in goal, while Maya Yoshida stands in for Dejan Lovren. Morgan Schneiderlin and Paul Lambert also miss out, with Dani Oslvaldo and Steven Davies replacing them.
Southampton: Gazzaniga, Clyne, Yoshida, Lovren, Shaw, Wanyama, S. Davis, Ward-Prowse, Lallana (c), Rodriguez, Lambert.
Aston Villa: Guzan, Bacuna, Vlaar, Clark, Baker, Luna, El Ahmadi, Westwood, Delph, Agbonlahor, Kozak.