Andre Villas-Boas saw his side throw away a 1-0 lead in the last ten minutes at Carrow Road, going on to lose 2-1 as Clint Dempsey missed a last minute penalty.
They are going well in the league however, having won five out of their last six, and moved up to fourth spot last weekend following their 2-1 win at Southampton.
Wigan endured Capital One Cup humiliation in midweek, losing to League Two Bradford City. Roberto Martinez needs to get the defeat out of the players systems as soon as possible, with his side sitting in 15th place and hoping to build on last weekends win over West Ham.
They have a wretched record at White Hart Lane however, and suffered a humiliating 9-1 defeat at the Lane in 2009.
Tottenham will be without Mousa Dembele who is struggling with a hip injury, whilst Wigan have no new injury concerns to contend with.
Prediction: Tottenham 3-1 Wigan