Scunthorpe have not conceded a goal in any of their last 282 minutes of league football at Glanford Park.
Fleetwood lost 1-0 at home to the Iron back in October in the only previous competitive meeting between the sides.
Sam Winnall has netted five times in his last five games for the Iron.
Jon Parkin has scored three goals in his last four league games for the Cod Army.
No side has won more points from the last 10 league games than Scunthorpe (22).