After winning the first three league clashes against Hartlepool contested at home, Oxford have lost their last two against them.
Hartlepool have won three of the last four encounters with Oxford in the league, but did lose the reverse fixture earlier in the season 3-1.
Hartlepool have scored 12 goals from outside the area in open play this campaign; a league-high.
Pools are without an away win in four attempts, losing twice (D2); their longest winless run this season is five.
Oxford have failed to win any of their last six league fixtures, losing four (D2); conceding at least two goals in four of these games.