Southend have won six of their last seven league encounters with Oxford United (L1).
Oxford have lost their last four league games away to Southend, failing to score on two occasions.
Oxford ended a run of six games without a win (D2 L4) with victory in their last league match.
Southend have drawn eight of their last 12 in League Two, winning none.
Oxford are without an away win in seven attempts, drawing four and losing three.