Chile have never beaten Spain in their 10 previous encounters (D2 L8).
Spain have won the two previous meetings with Chile at the World Cup: in 1950 (2-0) and in 2010 (2-1). The game in 1950 was played at the Maracanã; which is where this encounter is taking place.
Chile have lost their two previous World Cup games against the defending champion, both against Brazil (in 1962 and 1998).
In their group opener against the Netherlands, Spain conceded 5+ goals in an international for the first time since losing 6-2 to Scotland in June 1963.
Only once before had Spain conceded 5+ goals in a World Cup game (1-6 vs Brazil in Brazil in 1950).
Spain lost their opening game of the 2010 World Cup finals (0-1 v Switzerland) but became the first team to ever lift the World Cup trophy after having lost their opening game of the tournament.
Spain's 1-5 defeat to the Netherlands was the heaviest margin of defeat by a reigning World Cup champion in the history of the tournament (four goals). The previous heaviest were Brazil losing 0-3 v France in 1998 and West Germany losing 3-6 v France in 1958.
Alexis Sanchez has been involved in seven of the last eight goals that Chile have scored (six assists and one goal).
Spain have not lost back to back internationals since October 2006 (2-3 v Northern Ireland and 0-2 v Sweden).
The Spaniards conceded more goals in 90 minutes against Netherlands (5) than they had in their previous nine international matches combined (4).
Spain have won just one of their last five internationals played at a neutral venue (L2 D2) and that victory was a 2-0 win over El Salvador (FIFA Ranked 68th) in Washington earlier this month.