This will be the first time Swansea City have played an Italian team in European competition (excl. qualifiers).
Napoli have won just one of their last 11 away games in the Europa League (D3 L7).
After keeping clean sheets in their opening two Europa League matches, Swansea have conceded exactly one goal in their last four.
The Swans have also failed to score in their last two Europa League games, losing 1-0 on each occasion.
The Blues have also won only one of their previous eight matches at the Last 32 stage of the competition (D3 L4), being defeated in each of the last three.
In fact, Napoli's last (and only) away win at this stage came in November 1974 against FC Porto, drawing four and losing four since.
Of the sides who qualified to the Last 32, only Real Betis (1) scored fewer home goals than Swansea in the group stage (2).
The Italian side have never won a European game against a side from England, Wales or Scotland losing seven of their eight trips to the United Kingdom (D1; includes European Cup, UEFA Cup, Cup Winners Cup and Fairs Cup).
After three successive home defeats, Swansea have won their last two at the Liberty Stadium in the Premier League without conceding.
Napoli's last two eliminations in this competition have come at the Last 32 stage; to Villarreal in 2011 and Viktoria Plzen in 2013.
Only Spurs (69.7%) had a better average possession in the group stage than the Swans (63.0%).
Napoli have won just three of their last 18 away games in all European competitions (excluding qualifiers), drawing four and losing 11.