Brighton have faced Hull twice before in the FA Cup, winning both games, in Round Three in 1985 and Round Four in 1986.
On home soil, the Seagulls have lost just one of their last 11 FA Cup games, winning six and drawing four.
The Tigers have won their last three FA Cup games on the road, netting two goals in each of them and shipping just one in total.
Brighton have won just two of their last 11 FA Cup games against Premier League opposition, although those two victories, both against Newcastle United, have come in the last four clashes with top-tier opposition.
Hull have lost just one of their last 11 matches in the FA Cup against teams from a lower division, winning eight and drawing two.
The Seagulls have made it to the Sixth Round of the competition only twice in their history, in 1983 when they reached the final and in 1986 when they were put out in the Sixth Round by Southampton.
Hull have only made it past the Fifth Round on five previous seasons, the last of which was 2009 when they were eliminated by Arsenal in the Sixth Round 2-1.
Brighton have won four successive home games in all competitions, all by a 1-0 scoreline.
There have been just six goals scored in the last six competitive matches at American Express Community Stadium.
Hull City have alternated between a defeat and a win in their last six competitive away games. If this run is to continue, Hull will have to suffer a defeat in this game.