These two sides have met three times previously in the FA Cup, all in the third round (1976, 1996, 2006), with Charlton winning all three games.
Addicks’ boss Chris Powell played for the club the last time they met Sheffield Wednesday in the FA Cup (2006), helping his side to a 4-2 away win.
The Owls have lost each of their last three FA Cup fifth round ties and haven’t progressed past this stage since the 1996/97 season, when they beat Bradford in this round before losing to Wimbledon in the sixth round.
On the road, the Addicks have lost just one of their last four FA Cup games, winning the other three without conceding a single goal.
At Hillsborough, the Owls have lost just one of their last seven FA Cup games, winning five and drawing one.
Sheffield Wednesday have lost their last two matches at Hillsborough without scoring.