The Blues have scored in 13 of their last 14 League Cup matches; averaging 2.5 goals per game in that time.
The last competitive meeting between the two sides came in the third tier of English football in April 1995 – The U’s were 1-0 winners on the day.
This will be the first time Birmingham City and Cambridge have met in the League Cup.
This is Cambridge’s first appearance in the League Cup since 2004/05. They’ve progressed just once in their last eight attempts in this competition against teams from higher divisions.