Sone Aluko scored Hull\'s winner in the previous round against Trencin.
Lokeren\'s last appearance in the Europa League qualifying phase came in 2012/13, being knocked out on away goals by Viktoria Plzen in the playoff. They did win the home leg 2-1.
Hull have won just one of their last seven away games across all competitions, though this did come against QPR on Saturday.
Lokeren have lost their four previous European games against English sides, losing twice to Newcastle United in 2001 in the Intertoto Cup and Manchester City in 2003 in the UEFA Cup.
In the last 10 European games between English and Belgian sides, the Belgian side has been victorious just once (Zulte Waregem v Wigan in 2013), with five English wins and four draws.
In fact, English sides have lost just one of their last 14 games on Belgian soil in European competition (W8 D5).