With several Champions League and domestic cup meetings over the years, including last seasons FA Cup final, this fixture has become one of the most looked forward to in the Premier League calender.
Fernando Torres is set to line up against his former club for the fourth time since his acrimonious departure in January 2011. The Spaniard has yet to score against his former employers, with Liverpool defender Martin Skrtel coming out this week saying how he is desperate to keep things that way.
Chelsea’s slip up at Swansea last time out saw them lose their place at the top of the table for the first time in months, however a dramatic Champions League win in midweek will have restored confidence.
Liverpool go into the game on the back of two straight Premier League draws, although Luis Suarez looks in sensational form, having scored an early contender for goal of the season in the 1-1 draw with Newcastle last time out.
Rodgers left Suarez and the other big names behind for their 1-0 loss to Anzhi in the Europa League on Thursday.
Ashley Cole is set to miss the game with a hamstring injury, whilst John Terry will be pushing for a start having completed his four game ban.
Liverpool rested Steven Gerrard, Luis Suarez, Joe Allen, Nuri Sahin, Daniel Agger, Jose Reina, Glen Johnson, Raheem Sterling and Jose Enrique for their midweek Europa League game, with all expected to return to the starting line up as Rodgers goes in search of would be just his third Premier League win in charge.
He will be boosted by the fact Liverpool have emerged victorious from their last three visits to Stamford Bridge.
Prediction: Chelsea 1-1 Liverpool