Leicester travel to Manchester this weekend knowing they're just one win away from sporting immortality - they need only three points from three games to crown themselves champions after Tottenham slipped up at the Lane with a 1-1 draw against West Brom on Monday night.
At the other end of the table, Norwich have now fallen into the drop zone for the first time in over two months, and their tough run of upcoming fixtures starts at Arsenal as they hope to salvage their Premier League status.
Fellow relegation rivals Sunderland travel to Stoke, and Newcastle host FA Cup finalists Crystal Palace as the fight for survival continues.
Looking ahead to the weekend’s action, FootballFanCast predict who will be the winners and losers of this week’s fixtures.
WINNER - Wes Morgan
At Nottingham Forest and Kidderminster before his 2012 move to the Foxes, Jamaica international Wes Morgan wouldn’t have believed you if you told him he’d be a Premier League winning captain in four years' time.
Well Wes, that most unlikely of dreams is about to come true. Leicester - as much as they won’t admit it - will be playing with a winner’s freedom at Old Trafford this weekend. Don’t expect to see the cagey 1-0 specialists we have in previous weeks; expect a sprint towards the finish in what has been a marathon season.
Morgan has been colossal all season for Claudio Ranieri’s side, earning himself a spot in the PFA Team of the Year. For a man Paul Merson described as ‘awful’ at Nottingham Forest, he hasn’t done too badly.
LOSER - Jamie Vardy
Although he is not really a loser, Jamie Vardy will be devastated to miss out on the parade this weekend if Leicester are to bring home the title.
Having bagged 22 goals this season; broken Ruud Van Nistelrooy’s decade-old scoring record; earned himself an England call up and been named in the PFA Team of the Year; it hardly seems fair that the former non-league star will miss out on a moment of sporting history.
His over the top reaction to his silly sending off against West Ham in their 2-2 draw earlier in the month earned Vardy a two match ban, and was altogether, well, silly, really. Sorry, Jamie.
WINNER - Sergio Aguero
The Argentine will be at it again this weekend, quietly going about his business as usual. Overlooked once more for both PFA Player of the Year and the PFA Team of the Year, Aguero is still in contention for the Golden Boot this season having scored 23 for the Sky Blues.
The former Atletico Madrid striker will be looking to add to his tally of 101 Premier League goals this weekend, a feat which he achieved quicker than any other player bar Alan Shearer.
Southampton’s defenders will need to be at their absolute best if they are to keep City’s star man quiet, but somehow I don’t see it happening.
LOSER - Jakob Haugaard
Three weeks in a row Stoke City have now conceded four goals. That’s 12 in three games for you non mathematicians out there, and has put a downer on an otherwise excellent season for Mark Hughes and his side.
Haugaard has been one of a guilty bunch contributing Stoke’s awful form of late, and is yet to keep a clean sheet for the club, conceding a total of 11 goals in only four appearances for the Potters.
Sunderland look revitalised and with in-form Jermain Defoe looking to break into the top 10 Premier League goalscorers of all time list before the season ends (he’s three behind Robin Van Persie), the young Dane will be lucky not to concede more than one yet again.
WINNER - Kolo Toure
The experienced Ivorian’s future is a little at sea at the moment, after he admitted he wasn’t sure where he stands with Liverpool next season.
Manager Jurgen Klopp, however, has given the former Arsenal and City man a big boost, reassuring Toure he sees the defender firmly in his future plans at the club after his recent good run of form.
With Mamadou Sakho having seemingly ruined his Anfield career, and Martin Skrtel not favoured by the club’s eccentric German manager, Toure may be given his chance to shine against struggling Swansea this weekend. Yaya’s older brother will hope his performance will be enough to earn him a starting position in the Europa League final should Liverpool make it past Villarreal in the semis.