Nani has struggled to impress new United boss David Moyes and so the Red Devils may be happy to cash in on the Portuguese international as they have their own list of transfer targets for the New Year.
Juventus are hoping to boost their squad that already boasts former Premier League players such as Carlos Tevez and Paul Pogba.
United may accept a bid of around £8million for the 27 year old who has been urged to find some constancy by Moyes.
The former Everton manager looks to have settled on Adnan Januzaj and Antonio Valencia as his main wingers with Ryan Giggs and Ashley Young as back up.
This leaves Nani with a real fight to make the squad, along with Wilfried Zaha, and with a World Cup spot to fight for in the second half of the season; a move away from Old Trafford seems likely for the winger.