Hughes, who has been in charge of Rangers for ten months helped the club to Premier League safety last season, but has left the club in an ominous position this season despite spending over £21million on new signings in the summer.
QPR’s last games against fellow strugglers was dubbed ‘El Sackico’ and the 3-1 defeat has proved the fate for the Welshman.
A statement from the club said “Queens Park Rangers as of today have terminated the contract of Mark Hughes with immediate effect.”
“Mark has shown integrity and professionalism during his time at the club, but ultimately the circumstances we find ourselves in have left the board with very little choice but to make a change.”
QPR travel to Hughes’ former club Manchester United tomorrow, with Mark Bowen and Eddie Niedzwiecki will take control of the side.
Rangers are the only club in all four division to yet win a game this season as they sit five points adrift of safety on just four points from the opening 12 games.
Former Tottenham manager Harry Redknapp has been made favourite to take over from the outgoing Hughes.