Maurucio Pochettino makes four changes to the side that narrowly lost 3-2 at home to Aston Villa in mid-week.

Calum Chambers, Jose Fonte, Jack Cort and Dani Osvaldo all start for the Saints as they attempt to put an end to their current run of four Premier League defeats on the bounce.

Manuel Pellegrini also rings the changes, with James Milner and Alvaro Negredo replacing Edin Dzeko and Jesus Navas in the starting line up at St. Mary’s. Costel Pantililmon keeps his place in goal, meaning Joe Hart reamains on the City bench.