But, Pochettino is confident that he can lure his fellow countryman to St Mary’s Stadium, as he looks to add some creativity to his central midfield options.
Biglia is reportedly keen to leave Belgium and has gone on strike in an attempt to force through a January move.
The 26-year-old arrived at Anderlecht in 2006 from Independiente, and is said to feel that he is need of a new challenge.
Pochettino is keen to bring in a few fresh faces before the end of the month as he looks to stamp his personality on the south coast club’s squad.
Although Biglia is believed to be his top target, the Argentine is also looking to bring in Joan Verdu from his former club Espanyol.
The midfielder was a key man under Pochettino during his spell in Spain, and at 29 would likely be available for a reasonable fee.
He may also look to improve his defensive options, with the club having conceded 40 goals this season.