Wickham has struggled at the Stadium of Light since completing a £12million move from Ipswich Town three years ago.
He has managed just one Premier League goal during his Black Cats career so far, but does not turn 21 until next Monday.
And Poyet is hoping Wickham can start to fulfill his potential as his Sunderland side look to avoid relegation over the final few weeks of the season, starting with the game against Liverpool at Anfield tonight.
“We need a big impact now,” said the Uruguayan, whose side have not won a Premier League game since the 3-0 win over Newcastle at St James’ Park on February 1.
“We need something to happen to change the mood.
“If you were in a lower division, you’d probably look to sign a player on loan to have an impact. Another club might sack their manager and bring in another one, although I obviously hope that doesn’t happen here. But it’s that type of thing we need.
“We need something to happen, and I need to find that season-changing moment. Between the Liverpool game and Monday against West Ham at home, I have to find something.
“It could be Connor Wickham because there is a big possibility he will start at Liverpool. Connor’s going to get a great chance now.
“I would like Connor to look at this as though we have just signed him for the first time. He’s a new player, nobody knows him, and he’s a young English striker with incredible powers.
“He’s coming to help us get away from relegation. If he has that impact, that will be fantastic. It will be the ‘bang’ we need.”