‘s 1-0 victory over West Brom.
The striker is said to have damaged his ligaments in a challenge with Baggies front-man Shane Long and after the game, Spurs manager Andre Villas-Boas confirmed the worst.
“We’ll have to scan it to see if there is more damage, but hopefully it will only be two to three weeks, he has some ligament damage to his ankle. We will have to see the full extent of the injury. But we will miss him badly,” he told the Daily Mail.
The Portuguese also confirmed that Defoe has been withdrawn from the England Squad for Wednesday’s game against Brazil.
Villas-Boas was forced to change his tactics after the injury and replaced Defoe with new signing Lewis Holtby, moving Dempsey into a more central attacking role.
Villas-Boas has said that it was a ‘gamble’ not to secure the signing of another striker during the Premier League January transfer window, after losing out on Nacional striker Damiao on deadline day after a deal could not be reached.
They are due the return of Emmanuel Adebayor after Togo were knocked out of the African Cup of Nations, but Spurs are worryingly still short of a strong attacking presence. Villa-Boas however, remains confident that they will cope with the other goalscorers in the squad chipping in.
“It is difficult without Defoe but we have to adapt as and hope for his comeback as soon as possible,” he added.