The Italian defender is currently thought of as one of Serie A’s best enforcers after establishing himself as a first-team regular at his current club following a difficult spell as a youngster at AC Milan.
A host of Cagliari’s domestic rivals have been sniffing around the Azzurri star, but it is understood that Spurs very keen.
The Londoners have been linked with the 27-year-old on a number of occasions over the course of the past few months, but now it is thought that their interest has become more serious.
Astori is seen as a direct replacement for current star centre-half Jan Vertonghen, who is said to be edging towards a move away from White Hart Lane in search of Champions League football.
The silky defender is valued at around £8m, and despite Tottenham’s managerial uncertainty chairman Daniel levy is rumoured to be willing to push through a swoop.
Astori has made 33 appearances for Cagliari this term, helping them to steer clear of relegation.