The Saints have already sold five big name stars from their 2013/14 campaign, with Dejan Lovren, Adam Lallana and Rickie Lambert having moved to Liverpool, Luke Shaw to Manchester United and Callum Chambers to Arsenal.
And now Spurs are ready to get in the act by nabbing Rodriguez and Schneiderlin.
Both players are thought to be valued at around £20m-£25m by the South Coast club, who have already raised around £80m through sales this transfer window.
Mauricio Pochettino – another to have left St Mary’s Stadium in recent months – is desperate to get the pair to White Hart Lane, even though J-Rod will miss the opening weeks, and possibly months, of the new campaign through injury.
Rodriguez is seen as an ideal man to bolster the Lilywhites’ attack, while Schneiderlin’s presence at the World Cup have seen his reputation skyrocket.
Club record signing Dani Osvaldo could also be sold in the coming weeks, with the disruptive Italian attracting serious interest from his homeland.