Spurs are thought to be keen on the 29-year-old Argentine, who has been consistently impressive during his three-and-a-half year stint in France.
White Hart Lane chief Andre Villas-Boas is believed to be looking to strengthen his attacking options at the end of the season, and is thought to be interested in Lopez.
The two sides are due to meet for their last-32 second leg tie later this week, and with the versatile attacker likely to start for Lyon, Tottenham’s scouts will have a good opportunity to judge his abilities.
According to reports, the North Londoners were close to drafting in the South American star last month, but were unable to tie up a deal ahead of the transfer deadline.
Lopez’s current contract is set to expire at the end of the season, meaning that Spurs would not have to pay a transfer fee for his services.
This, coupled with his ability to play all across the front-line, has made him an attractive option for AVB, whose squad has, at times, been shown to be slightly too thin.
Arsenal have been linked with Lopez in the past, but is unclear as to whether they are still keen to make a move.
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