The Premier League club have made an enquiry about the Chilean attacker, who is rumoured to be available with Barca boss Tito Vilanova no longer seeing him as key to his first-team plans.
The Catalans are said to be chasing Brazilian sensation Neymar and may look to move the man they signed from Udinese last year to fund a potential deal.
This has alerted Andre Villas-Boas, who is believed to be keen to add greater depth to his squad.
A potential stumbling block in any deal could be the Spanish side’s asking price. Having paid in excess of £30m to bring the attacker to the club they are likely to be looking to recoup much of their outlay, meaning a bid of around £20m may be needed.
Equally adept in a wide or central role, Sanchez would add another dimension to Spurs’ attack and provide competition to established players such as Gareth Bale and Aaron Lennon.
The 23-year-old has struggled to recreate the form that made him one of the most sought after players in Europe since arriving at the Nou Camp and even admitted recently that his performances have been below par.
Liverpool are also rumoured to be interested, but the lure of life in London and Tottenham’s greater chances of Champions League football may be a deciding factor.