Nigel Adkins men have the worst defensive record in the division, having conceded an alarming 26 goals already, and currently sit in 19th position.
Adkins is also under pressure following their midweek Capital One Cup defeat to Championship side Leeds United, a defeat the manager shouldered the blame for after the match.
Steve Clarke will also be desperate for the points, having seen his side suffer back to back Premier League defeats, although rather unluckily losing in the last minute on both occasions.
The Hawthorns has been something of a fortress this season, with Manchester City the only side to come away with a win, whilst the likes of Liverpool and Everton have both been turned over.
Prediction: West Brom 3-1 Southampton