Patrick Vieira‘s side were humbled 4-0 at home by Spurs but go into Saturday’s game as favourites, against a Saints side that look devoid of confidence under new manager Nathan Jones, having lost their last six Premier League games on the trot.
After reaching the semi-finals under Vieira last season, the Eagles will be targeting another strong run in England’s most recognised cup competition but will need to be much improved if they want to get past Southampton.
Vicente Guaita has been the first-choice goalkeeper for all of this season but Sam Johnstone should get a chance in between the sticks for this cup fixture.
There are two changes at full-back, as both Nathaniel Clyne and Joel Ward disappointed in the defeat against Spurs, so Chris Richards and Jairo Riedewald are handed opportunities at right-back and left-back respectively, with Marc Guehi and Joachim Andersen continuing in the middle.
There is one change in defensive midfield, as Luka Milivojevic comes into the side for Jeffrey Schlupp, partnering Cheick Doucoure in the middle of the park.
Eberechi Eze, Wilfried Zaha and Michael Olise all keep their spots in midfield, in the hope that their creativity and flair can unlock a shaky Southampton defence, which has shipped the third-most goals in the top flight so far this season with 32.
The final change sees the “fantastic” Jordan Ayew drop out of the side, as he still boasts just one goal in the Premier League this season, with Odsonne Edouard deserving a start up front in his place.
Given their last two home games have finished 3-0 and 4-0 to the opposition, Vieira needs a much better result in the cup at Selhurst Park on Saturday, or the pressure could quickly build on the French manager.