Chelsea's clash with Manchester City this Saturday represents the most significant contest in the Premier League so far this season, last term's champions hosting arguably the biggest threat to their title defence.

Indeed, the Citizens have started the campaign in emphatic fashion, scoring 21 goals in six games and dropping just two points to move to the top of the Premier League table.

Accordingly, it's vital Antonio Conte gets his tactics and squad selection perfect this weekend and as things stand, there's one notably contentious department - the defence.

David Luiz is still serving a domestic suspension, so Chelsea will be without arguably their most important defender for Saturday's game.

Which in turn questions whether Gary Cahill should keep his place in the starting line-up after featuring in the 2-1 win over Atletico Madrid in midweek, having been benched for Chelsea's 4-0 victory over Stoke City last Saturday.

Conte appears to prefer summer signing Antonio Rudiger in the left centre-back slot and Andreas Christensen certainly hasn't let the Blues down when utilised in the central role.

So, Chelsea fans, considering the experience Luiz's absence takes away from the backline, would you start the 57-cap England international against City? Let us know by voting below...