West Ham United play host to London neighbours Tottenham Hotspur at the London Stadium on Saturday in what is one of the standout Premier League fixtures of the weekend, and it is a chance to once again put their ever-increasing rivalry to the test.

While many Irons and Spurs supporters would consider Millwall and Arsenal respectively to be their arch-enemies, this derby has also proven to be pretty fierce for a number of decades.

With Tottenham Hotspur having a 100% record on the road in the league this season and Slaven Bilic’s men taking four points from their last two top flight fixtures having lost their opening three, it should be another entertaining clash in east London.

The tension between the two clubs has certainly built even more during the Premier League era following a number of incidences, and we could even see another one on Saturday.

Here are 10 moments that shook the rivalry between West Ham and Tottenham…

Manuel Lanzini's goal

Rewind five months, and Tottenham Hotspur were chasing down leaders Chelsea in the race to win the 2016/17 Premier League title having won 10 matches in a row.

They faced West Ham at the London Stadium on Friday May 5 knowing that they could close the gap on the Blues to just a point with victory in east London, and they looked odds-on to do so with the hosts virtually safe after a tough first season in their new home.

Slaven Bilic’s men had other ideas though and Lanzini’s 65th-minute goal proved to be the winner, and ended Mauricio Pochettino’s men’s chances of lifting their first ever Premier League trophy.

The Irons fans certainly enjoyed the moment and while they will want more of the same on Saturday, Spurs will surely be out for revenge.

Jermain Defoe transfer

Football - FA Barclaycard Premiership - Birmingham City v West Ham United  - 11/5/03 
West Ham's Jermain Defoe looks dejected at the end 
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Following West Ham’s relegation to the Championship in the 2002/03 season, striker Jermain Defoe quickly handed in a transfer request.

However, he ended up staying with the Irons and scored 15 league goals in England’s second tier to attract admiring glances from Premier League clubs – including Tottenham.

The attacker was still a West Ham player on transfer deadline day during the January window and supporters would have been hopeful that they were keeping him – until just before the window slammed shut anyway.

The Hammers announced minutes before the 5pm deadline that Tottenham had signed Defoe for £7m plus Bobby Zamora in exchange in what was a huge blow for the Championship side.

Ravel Morrison's goal

Spurs 0-3 West Ham: Ravel Morrison scores

Tottenham had started the 2013/14 season in fine form by losing just one of their opening six Premier League fixtures and taking 13 points from the other five, and they would have been confident of beating a lowly West Ham – who found themselves in the bottom three – at White Hart Lane.

The visitors had other ideas though, with Winston Reid giving them a shock 66th minute lead with a close-range finish, before a ricochet off of Ricardo Vaz Te doubled their advantage six minutes later.

While there were question marks over his attitude, Ravel Morrison was beginning to show some form on the pitch for the Irons and he certainly saved the best until last, picking up the ball in his own half before embarking on a magnificent solo run and brilliantly dinking the ball over Hugo Lloris.

Freddie Kanoute transfer

Following West Ham’s shock relegation from the Premier League in 2003, Kanoute was another of those that wanted out at Upton Park.

The striker had scored five goals in 17 Premier League appearances – with just 12 of those being starts – as the Irons dropped down to the Championship, and he was often criticised by his own fans for his laid-back attitude.

In that respect Tottenham supporters may have been shocked that they signed the Mali international in a £3.5m deal, and they were proved to be right in hindsight as he went on to net just 14 Premier League goals in 59 top flight outings.

Paul Stalteri's dramatic winner

Football - West Ham United v Tottenham Hotspur - FA Barclays Premiership - Upton Park - 06/07 - 4/3/07 
Tottenham's Paul Stalteri scores their fourth goal  
Mandatory Credit: Action Images / Tony O'Brien 
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It was March 2007 and West Ham were bottom of the Premier League table and looked to be in real danger of falling back into the Championship.

Without a win in 10 games, they needed a big performance when Tottenham came to Upton Park and after taking a 2-0 lead through goals from Mark Noble and Carlos Tevez, it looked as though Alan Curbishley’s side were going to do it.

However, Jermain Defoe scored a penalty before Teemu Tainio netted a fine volley to equalise for Spurs, but the scoring wasn’t done there.

Bobby Zamora looked to have won it for the hosts when he headed in five minutes from time, but a Dimitar Berbatov free-kick and an injury-time winner from the most unlikely of sources – Stalteri – gave the visitors all three points.

As we all know, it didn’t prove to be a critical defeat for the Irons as Carlos Tevez saved them on the final day at Manchester United.

Scott Parker transfer

After finishing bottom of the Premier League table in the 2010/11 season, West Ham once again found themselves back in the Championship and in danger of losing some of their best players.

With the summer transfer window starting to draw to a close they would have been hoping to keep hold of Parker – who had been voted the Football Writers’ Association Footballer of the Year for his committed attempt to keep the Irons up – as they looked to make an immediate return to the top flight.

However, the England international handed in a transfer request just days before the window was due to slam shut and completed a move to Tottenham on August 31 in what was a bitter blow to the Irons.

Lasagne-gate

It was May 2006, and Tottenham only needed to match Arsenal’s result against Wigan Athletic when they faced West Ham at Upton Park in order to clinch the final Champions League spot in the Premier League.

It was almost in their hands, but disaster struck the night before when their pre-match Lasagne meal caused an outbreak of vomiting and diarrhoea throughout the squad and it was obvious that a number of the players were off-colour on the pitch.

Michael Carrick, Robbie Keane, Edgar Davids, Michael Dawson and Aaron Lennon were just some of the player affected, and the situation was so drastic that Spurs even requested the match to be postponed, only to be told they could face a points deduction if that happened.

So they played on and even though Carl Fletcher gave the Irons the lead after 10 minutes, Jermain Defoe managed to find an equaliser just before the break.

However, the Spurs players were running on empty and when Yossi Benayoun scored in the 80th minute it was game over, and despite spending the majority of the campaign in the top four, they lost out the spot to arch-rivals Arsenal on the final day.

Michael Carrick transfer

Following West Ham’s relegation to the Championship in 2003, they lost the likes of Joe Cole, Paolo Di Canio and Glen Johnson, but Carrick was one of the players they managed to keep hold of for the entire campaign.

The midfielder stayed to try and help the club return to the Premier League, but they ended up missing out on automatic promotion before losing to Crystal Palace in the play-off final.

Carrick had decided enough was enough and after refusing to extend his contract that was due to run out the following summer, he was sold to Tottenham.

Having lost Jermain Defoe to their London rivals just a few months earlier, it would have been another bitter pill to swallow.

The Olympic Stadium bid

West Ham and Tottenham went head-to-head for tenancy of the Olympic Stadium following the London 2012 Games, but it was the Irons that came out on top with it now being their permanent home.

The north London outfit’s plan had been to demolish the 80,000-seater athletics ground and rebuild a 60,000-seater stadium on the same bit of land, but they lost out.

Even after West Ham had won the race for the venue, The Telegraph says that Spurs still proposed a one-season ground share while their White Hart Lane home was being renovated, which was understandably not met with any consideration.

Tottenham were also accused of spying on West Ham’s initial bid for the tenancy, with a number of arrests made.

It is certainly a series of events that means relationships between the likes of Karren Brady and Daniel Levy are extremely strained.

Emmanuel Adebayor negotiations

The strained relationship between the two clubs at board level ultimately meant that West Ham missed out on signing Adebayor from Tottenham in January 2015.

The Irons were keen to bring the striker to Upton Park after he had been frozen out under Mauricio Pochettino, and the centre-forward admitted that he preferred to join them over Queens Park Rangers or Crystal Palace – the other two interested clubs.

However, The Telegraph said that while Daniel Levy was prepared to subsidise a large chunk of the Togo international’s £100,000-a-week wages for both QPR and the Eagles, he wasn’t willing to do the same for the Hammers and a move failed to materialise.