Chris Brunt and Peter Odemwingie both face fitness battles ahead of Saturday's trip to Aston Villa.
Baggies striker Odemwingie, who netted a brace against Newcastle, has been unable to train this week with a groin problem suffered during the game.
Brunt has also been dogged by a groin strain in recent weeks and has missed some sessions, according to Roberto Di Matteo.
The Baggies boss said:"We have some problems. Odemwingie hasn't trained this week yet. He has got a groin problem.
"If he manages to train tomorrow, we have a chance. We have to wait and see how he is going to be tomorrow.
"Chris Brunt had to miss some training sessions so we just have to manage him and Peter and hope they will be available for Saturday."
The Baggies will be hoping to build on their current position of ninth in the table against their local rivals, who they could push further towards the relegation zone with a win.