Chelsea full-back Jose Bosingwa will miss the climax to the domestic season and the World Cup through injury.
Bosingwa has been told he requires further surgery on a knee injury which has already kept him out of action since December.
That rules the full-back out of the Premier League title run-in, closing stages of the Champions League and FA Cup plus Portugal's World Cup campaign in South Africa.
Bosingwa made eight appearances in the opening weeks of the campaign before being stricken by a ligament injury during a 2-1 defeat at Aston Villa on October 17.
"Bosingwa will be out for the season and have another operation, so that's him unfortunately – and he'll miss the World Cup as well," confirmed assistant manager Ray Wilkins.
Meanwhile, Wilkins also confirmed that fellow knee injury victim Michael Essien has suffered a setback in his own recovery.
The Ghana captain has been sidelined since December with a ligament problem and was thought to be close to making his return to action.
Speaking about Essien and Ashley Cole's recovery from a fractured ankle, Wilkins told the club's official website:"Michael Essien is doing well, there has been a slight complication which means it needs a couple of weeks longer.
"He's out (in France) with Ashley now and they're both doing extremely well, so from that point of view we're delighted with their recovery.
"It's difficult to give a timescale but hopefully he'll be fit as soon as possible because when we lose players of that quality it is damning on any side."