The newly-promoted side are in the relegation mire, and need to start picking up points to avoid the drop back to the Championship.
Cisse will be out to score against the Reds in midweek, even if he has a connection to his ex-employers.
“It’s a special club but, for an hour and a half, there is no mercy,” he told the club’s official website.
“When the whistle blows, that feeling will disappear. It was difficult to leave because it wasn’t my decision.
“Rafael Benitez told me, ‘You’re not in my plans’, so I had to leave. I was really sad because I did well in the short time that I played.
“But that’s the way it was and I have to accept it,” he concluded.
Meanwhile, Mark Hughes has admitted that he expects a difficult game against Kenny Dalglish’s men on Wednesday.
“It may be difficult for Liverpool to reach the teams above them. But they’ll give it a good crack because there’s a demand on their club to be successful,” he told the side’s website.
“They’ve got a huge European pedigree that they obviously want to maintain and be a part of.
“Their drive and ambition will always be there. Their fans and everything that surrounds Liverpool Football Club demands that they have Champions League Football,” he concluded.
By Gareth McKnight