PSV Eindhoven took the lead in the Dutch Eredivisie with a 4-1 win over NAC Breda on Sunday after Twente could only draw.
PSV and defending champions Twente were level on 50 points ahead of their respective matches, but Fred Rutten’s PSV side are now out in front with 53 points.
Visitors Breda got off to a bad start at the Philips Stadion when Nemanja Gudelj saw a straight red card after just 15 minutes.
Balazs Dzsudzsak gave PSV the lead in the 25th minute.
Anthony Lurling levelled for Breda on 64 minutes, but goals from Jeremain Lens, Ola Toivonen and Francisco Rodriguez wrapped up a comprehensive win for the hosts.
Twente meanwhile were forced to settle for a 1-1 draw at home to NEC Nijmegen.
Niki Zimling had NEC ahead after 17 minutes at De Grolsch Veste, but Emir Bajrami equalised.
A point each leaves Twente second, two points behind PSV, while NEC are 10th.
Mounir El Hamdaoui’s goal in the 11th minute at the Amsterdam Arena gave Ajax a 1-0 win over visitors VVV Venlo.
Ajax are third, three points behind Twente and five behind PSV.
Venlo, who finished with 10 men following the sending off of Ken Leemans in the 74th minute, are second from bottom, five points above last-placed Willem II.
Two late goals saw ADO Den Haag snatch a point at home to Feyenoord.
Visitors Feyenoord led through a first-half double from Luc Castaignos at the Het Zuiderpark and the strugglers looked on course to collect three valuable points, before Charlton Vicento pulled one back for the hosts in the 81st minute.
Dmitry Bulykin then struck with five minutes remaining to ensure a share of the spoils for ADO.
The draw leaves ADO fifth and Feyenoord 15th, just three points outside the relegation zone.
Vitesse Arnhem climbed above Feyenoord and into 14th place following a 2-0 win at home to De Graafschap.
Bonno Wilfried broke the deadlock for the home side 72 minutes in at the Gelredome and Serbian Nemanja Matic – on loan from English Premier League club Chelsea – doubled the lead with six minutes to go.
The defeat leaves De Graafschap 12th, just a point better off than Vitesse and only four clear of the drop zone.