Sir Alex Ferguson is sure that veteran goalkeeper Edwin van der Sar will retire from the game at the end of the current Premier League campaign.
With his wife Annemarie suffering a serious brain-related illness last year, Ferguson believes he will want to spend more time in his homeland as she continues her recovery.
"I have come to accept this will be Edwin's last season," Ferguson said."It's sad but the difficulty for a goalkeeper when he gets to 40 is something which happened with Peter Shilton.
"All of a sudden, because of age, Shilton's form just collapsed and I don't think Edwin would want that. He is such a proud man and it's going to be a big loss.
"We had a chat last season about how he saw his future and he explained to me his plans, and nothing has changed from then.
"It's difficult because he has his wife's health to consider after her illness.
"She is fine now and seems to be really good but she still has treatments to get in Holland, with physiotherapy and things like that. So for him to be here with us would be difficult."