The 20-year-old is on loan at Molineux from Arsenal, but picked up an injury against QPR on Saturday, and had to be replaced in the first half of his side’s 2-1 win.
Mick McCarthy’s men have confirmed that extent of the knock, and wished Frimpong all the best in his recovery.
“Emmanuel Frimpong has ruptured the anterior cruciate ligament in his right knee in Saturday’s Barclays Premier League game at QPR,” a statement on the club’s official website reads.
“Frimpong, on loan at Molineux until the end of the season, will now see specialists in London over the next few days before having surgery and starting a programme of rehabilitation.
“The midfielder, who suffered the same injury to his left knee in 2010, had made an impressive start to his temporary spell at Wolves, catching the eye during his five appearances in gold and black.
“Frimpong is expected to be out for a number of months and will therefore miss the remainder of this season.
“Everyone at Wolves would like to thank the midfielder for his efforts whilst at the club and join Arsenal in wishing him a swift recovery,” it concluded.
By Gareth McKnight