Juventus have suffered a double blow, with midfielders Momo Sissoko and Alberto Aquilani both ruled out with injury.
Malian international Sissoko will be out for the next two months after scans revealed he would need knee surgery.
The 26-year-old has been battling to reach full fitness for much of the Serie A season, and it now appears as though surgery is the only option.
With the former Liverpool man expected to be transferred after this season, it could mean he has played his last game for the Turin club.
“The medical tests on Sissoko showed that surgery to clean up the cartilage in the left knee would be opportune,” a club statement read.
“On Tuesday, therefore, Professor Jambou will perform the operation in Bordeaux, France.”
Aquilani, meanwhile, will be out for 10 days with a thigh strain he suffered at training on Friday.
“Aquilani underwent tests at the Fornaca Clinic in Turin today,” a statement read.
“The results showed the right thigh muscle was stretched. His return is expected in around 10 days.”