Spurs last triumphed in the red half of Manchester in 1989 but ended that barren run with a sparkling performance with goals from Jan Vertonghen and Gareth Bale sending them in at the break with a two goal advantage.
Sir Alex Ferguson will be furious with his defence in what was the Red Devil’s second defeat of the season and left them four points behind Premier League leaders Chelsea.
A course of the Fergie hair dryer treatment will undoubtedly have been doled out in the dressing room at the break with Rio Ferdinand the main recipient. With England boss Roy Hodgson watching from the stands Ferdinand was at fault for Spurs opener in the second minute as his half-hearted challenge allowed Vertonghen enough space to strike a low shot that deflected off Jonny Evans and past Anders Lindegaard.
The hosts struggled to conjure any rhythm to their play as Spurs barely gave them a sniff of goal in the first half as Clint Dempsey and Moussa Dembele won the midfield battle with veteran pair Ryan Giggs and Paul Scholes. It was Dembele who had a huge hand in the away sides second goal just past the half hour mark with a superb run and pass to set up Bale who made no mistake with his finish.
Ferguson threw on Wayne Rooney and Michael Carrick after the interval but a crazy spell of three goals in as many minutes saw Nani reduce the deficit in the 51st minute, putting the finishing touches to a Rooney cross, before Dempsey punished Lindegaard after he spilled Bale’s effort 60 seconds later.
Shinji Kagawa reduced the arrears once again in the 53rd minute but Tottenham held on to secure a famous victory.