It will be the first time the Dutchman has come face to face with his former employers since leaving them for £24million in the summer, and will surely be expecting a tough reception from the travelling Arsenal fans.
Both teams go into the game on the back of Capital One Cup thrillers, with Arsenal coming back from 4-0 down to beat Reading 7-5 on Tuesday, and United going down 5-4 to Chelsea at Stamford Bridge, with both games going to extra time.
Goals look certain to come at Old Trafford, with United looking vulnerable at the back and often superb going forward, proving this in their 2-3 win at Stamford Bridge last Sunday.
Arsenal struggled to a 1-0 at home to QPR last time out, and will be slightly apprehensive of their trip to Old Trafford. The Gunners haven’t won in eight visits in all competitions, losing seven.
Ferguson will have a tough selection headache, with Javier Hernandez pushing for a start after scoring two goals in a week, whilst Wenger will decide whether to start Jack Wilshere after the midfielder played his first league game in over 18 months against QPR last week.
Prediction: Manchester United 3-2 Arsenal