Sam Allardyce makes five changes to the side that beat Tottenham Hotspur in the Capital One Cup on Wednesday night.
Spanish stopper Adrian makes his Premier League debut after impressing in that game, while James Tomkins, Mark Noble, Ravel Morrison, Mohamed Diame and Modibo Maiga return to the starting line-up at Old Trafford.
Wayne Rooney starts for Manchester United in an unchanged team to the won that comfortably brushed aside Aston Villa last weekend.
Confirmed #mufc team vs West Ham: De Gea Rafael Smalling Evans Evra Valencia Jones Cleverley Januzaj Welbeck Rooney.
— Manchester United (@ManUtd) December 21, 2013
TEAM NEWS: #whufc Adrian, Demel, Tomkins, Collins, McCartney, Noble, Morrison, Taylor, Jarvis, Maiga, Diame
— West Ham United FC (@whufc_official) December 21, 2013