Wigan Athletic have agreed an undisclosed fee with Hamilton for midfielder James McArthur.
The 22-year-old midfielder has been linked with several English clubs in recent transfer windows, but he will now join the Latics, subject to passing a medical at the DW Stadium.
Former Hamilton team-mate James McCarthy made the same move from Scotland to the Latics 12 months ago.
"The transfer of James comes exactly one year after James McCarthy moved to Wigan and I am confident that 'Auld' James will be just as successful in England," Accies chairman Ronnie McDonald told his club's official website.
"Our sadness at his departure is outweighed by our feeling of pride in his success and the way he acquitted himself in the Accies shirt.
"James is the third player to graduate from the youth academy to the English Premier League and great credit is due to all of our dedicated management, coaching and medical staff who have assisted him in his development.
"The terms of the sale agreement forbid the disclosure of the sums involved, but the Accies will receive a substantial initial fee and add ons based on appearances.
"We wish James every success in his new challenge, he fully deserves the financial rewards he will now enjoy."