Manchester police have taken the unusual step of warning players from both sides about their conduct ahead of Saturday's derby between United and City.
Eastlands will host the fourth meeting of the two rivals this season on Saturday lunchtime, with police keen to avoid any provocative player behaviour.
Back in January Gary Neville and Carlos Tevez became embroiled in a derby spat.
Tevez goaded former team-mate and United captain Neville after scoring in the first leg of the Carling Cup semi-final.
Neville responded with a hand gesture and the pair became embroiled in a war of words in the media during the ensuing days.
The two legs of the tie were marred by crowd disturbances inside and outside the grounds and Manchester police have taken the unusual step of contacting both clubs before the game in a bid to prevent further trouble.
"Our main aim is to ensure it is an enjoyable experience for all fans," explained assistant chief constable Ian Hopkins.
"This is a high-profile fixture and we have been working closely with Manchester City Football Club to ensure the day passes off peacefully."