The England striker missed his side’s 2-2 draw with Benfica on Tuesday night after picking up a hip injury in the 1-0 win over Swansea last weekend.
Rooney collided with Swans goalkeeper Michael Vorm, and suffered bruising to the bone as he feel heavily to the ground.
Mirror Football indicates that a Manchester United source has revealed that Rooney is less than 50-50 to face Alan Pardew’s men, and could again watch from the sidelines.
United had plenty of possession against Benfica in midweek, but without their talismanic attacker looked to be slightly devoid of direction and penetration.
Sir Alex Ferguson will hope his main man is fit for the clash, but may be forced to look at other options in Rooney’s absence.
The injury may pose a lifeline for out-of-favour forward Dimitar Berbatov, who started and scored against the Portuguese outfit on Tuesday, but Javier Hernandez will also be eager to secure a place in the starting XI.
United enter the weekend’s fixtures five points behind rivals and league leaders Manchester City, and will know that they can ill-afford to drop further points.
By Gareth McKnight