Tottenham have confirmed Jermain Defoe will be sidelined for three months with torn ankle ligaments.
Defoe was injured during England's 3-1 win in Switzerland on Tuesday evening and initial estimates suggested he would be out of action for four to six weeks.
However, scans following his return to north London have now revealed torn ligaments, so the outlook is worse for manager Harry Redknapp.
Defoe, who scored a hat-trick in last week's 4-0 Euro 2012 qualifying victory against Bulgaria, had netted one goal in four appearances for Spurs in the opening weeks of the new season.
The 27-year-old could now miss all of his club's Champions League group stages matches.
"Following a review by an ankle specialist, Jermain Defoe underwent surgery to repair torn ligaments in his right ankle yesterday evening," read a club statement.
"The striker was forced off with the injury during England's European Championship qualifier in Switzerland on Tuesday and has been ruled out of action for around three months."
Spurs also lost defender Michael Dawson for a number of weeks to ankle and knee ligament injuries picked up during the Bulgaria game at Wembley last week.