The England international has a throat infection, which has been a problem over the last week, and will be rested.
“Wayne is out tomorrow. He has a really bad throat,” the Scottish coach told Sky Sports.
“There were traces of it in Amsterdam and we gave him some medication but it got worse.
“He has been in bed over the weekend and came in today for the first time and we are trying hard to get him right for Sunday,” he admitted.
Ferguson went on to state that promising youngster Paul Pogba may well make an appearance, but the French starlet is not the only player in need of gametime.
“It is possible we could give Pogba a run-out,” said Ferguson.
“It depends because there are a lot of players who need a game; Nani, [Ashley] Young, [Javier] Hernandez, [Tom] Cleverley, [Chris] Smalling, [Phil] Jones.
“Those players will all play tomorrow and we hope to put a sprinkling of experience amongst it,” the coach concluded.
United lead the tie 2-0 after victory last week at the Amsterdam Arena.
By Gareth McKnight
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