Leicester City defender Timothy Castagne suffered a serious injury in Belgium's opening Euro 2020 encounter.
The 25-year-old collided with Russia's Daler Kuzyaev around the 27-minute mark on Saturday evening, suffering a double fracture in his eye socket, Sky Sports News reported.
Roberto Martinez's men went on to record a comfortable 3-0 victory in St Petersburg, but Castagne will play no further part in the tournament.
"Really bad news, sad to see Timothy Castagne is going to be out of the tournament," said Martinez after the game.
"He's had images taken, he's got a double fracture, and now we'll take the necessary treatment."
Castagne enjoyed an impressive maiden campaign in English football throughout 2020/21 following a £21.5m move from Serie A outfit Atalanta.
He made 34 appearances in all competitions for the Foxes, scoring two goals and providing four assists as the Midlands outfit narrowly missed out on a Champions League qualification spot.
A timeframe hasn't been placed on Castagne's recovery time just yet, but news that one of his key first-team players is set for a lengthy spell on the sidelines will surely leave Leicester manager Brendan Rodgers gutted.
The current FA Cup holders will be looking to break into the top four next term, and they will need their star performers to be fit in order to achieve that goal.
With fellow full-back James Justin also expected to be out for many months as he continues to recover from a serious knee injury, this is a potentially significant setback in Rodgers' summer plans.
Leicester were already expected to be in the market for a new defender following the departure of experienced duo Wes Morgan and Christian Fuchs, but they may feel the need for further reinforcements depending on the severity of Castagne's situation.
Belgium take on Denmark in their next Group B encounter on Thursday 17 June, although they'll have to do so without their first-choice right-back.
And, in other news...Rudkins masterclass: LCFC must seal £17m “goal machine” this summer, Rodgers needs him