Arsene Wenger is understood to have intensified his search for a central midfielder over the course of the last week, with Jack Wilshere set for an extended spell on the sidelines with an ankle injury.
The Frenchman is thought to be looking for a player with more defensive bite, and sees Sissoko as a good option.
The Magpies ace has been a big hit since his 2013 move to St James’ Park from Toulouse, thriving in the middle of Alan Pardew’s XI.
The 25-year-old was sent off during Newcastle’s loss at West ham on Saturday, but he has been praised heavily by his boss in recent times for his energetic and dynamic displays.
Although operating in a more advanced role for the North East club, Sissoko is at home in a holding role, where he could succeed ageing Spaniard Mikel Arteta at the Emirates Stadium.