The incident occurred in the dying seconds of the Reds’ 2-1 loss at home to their bitter rivals on Sunday when the Slovakian collided with the goalkeeper as he was chasing a loose ball.
Replays indicated that there had been contact between his boot and the United man’s leg, but the incident was not seen by any of the match day officials.
The FA subsequently reviewed the coming together, with an independent panel declaring that the Merseyside ace had intentionally stood on De Gea.
Skrtel appealed the call, but the three-match ban has been upheld.
The 30-year-old was seemingly critical of the FA shortly afterwards – he posted an image of clowns on his Instagram account (below) – and has now told his personal website that he does not feel guilty:
“It feels strange because we appealed against those charges and still I was hit by a three-match ban,
“I didn’t want to stamp on him. It was an accident and I didn’t do it on purpose. I don’t feel guilty.
“It was a long ball and he went towards me and I wanted to jump over him. Simple as that.”
Skrtel will miss Liverpool’s league games with Arsenal and Newcastle as well as the club’s FA Cup quarter-final replay at Blackburn.
Steven Gerrard will also sit out the same clashes for a stamp on Ander Herrera in the United game – which he was red carded for.