The sprightly attacker had met up with the Italy under-21 squad to face their Swedish equivalents, but it has been revealed that the Merseyside marksman has picked up a knock in training.
Borini underwent an MRI scan on Thursday, which has revealed that he will be on the sidelines for the foreseeable future.
“The Liverpool striker has fractured the scaphoid bone in his right foot and will miss the play-offs with Sweden,” read a statement released on the FIGC’s official website.
The news will come as a major blow for the Anfield club, who are already short of attacking options.
Borini and Luis Suarez are the only two recognised forwards in the first-team squad, with Brendan Rodgers being criticised over the release of Andy Carroll to West Ham on loan in the summer without a replacement being brought to the club.
The Reds will hope that Borini will not be on the sidelines for too long, but as yet there has been no estimation of how long the attacker will be unavailable for.
The Italian joined the Reds in the summer from Roma, but is yet to hit the net for his new club in the Premier League.
With Liverpool floundering in the bottom half of the table, Borini’s injury will place yet more pressure on Luis Suarez to deliver goals, with the Uruguayan already being targeted in a diving scandal of late.