Remarkably, the Argentina international makes it 41 injuries to United’s first team this season, adding to the rather unenviable list of currently sidelined stars at Old Trafford, including the likes of Luke Shaw, Daley Blind, Rafael and Phil Jones.
The £59million club-record signing only lasted 13 minutes against the Tigers at Old Trafford, before coming off with what appeared to be a hamstring problem.
He moved towards the United dugout and signalled that he needed to come off, before being replaced by Ander Herrera in a midfield reshuffle and quickly heading down the players’ tunnel for treatment in the dressing room.
Despite Di Maria’s sensational form this season, grabbing three goals and six assists in ten Premier League appearances, the Red Devils appear to be coping without him against Steve Bruce’s side.
They’re currently enjoying a 2-0 lead through goals from Chris Smalling and Wayne Rooney, and a win will see United return to fourth spot following Arsenal’s victory over West Brom in the Premier League’s lunchtime kick-off.
Di Maria’s injury however, if revealed as serious, would rather dampen the afternoon.