David Moyes’ side currently sit 11 points behind Liverpool in fourth place in the Premier League, and know that their most likely route to next season’s Champions League could be through winning this seasons competition.
With the likes of Barcelona, Bayern Munich and Real Madrid still in the competition, it looks set to prove a tall order for United, and Olympiakos are hoping the added pressure will work in their favour.
Former Real Madrid star Michel said: “We know there’s lots at stake for Manchester United in this match.
“We know Manchester United are not allowed to make any mistakes due to their position in the Premier League and we have to say probably this kind of situation may weigh too much on their players’ shoulders.
“It could be an incentive to them or it could be a burden on their shoulders.
“People say it’ll be a very demanding tie and that’s true. They are favourites but nothing says we can’t beat Manchester United.”
Olympiakos were ordered to shut a small section of their Karaiskakis Stadium as a punishment for displaying a Nazi banner during their group stage clash with Anderlecht in December.
“If you break the rules you have to pay,” Michel said.
“We hope it’ll be a lesson not just for us but for everyone in football, to show that you shouldn’t bring non-football things into a football match.”